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The programs available on the Internet are not professional, may contain errors and the number of options is limited. For this reason it is highly recommended to always check your installation with the official CD. For any problems please contact the official distributors and authors of the programs listed above.Immunomodulating effect of Bordetella pertussis vaccine in a murine model of experimental autoimmune myocarditis. Although Bordetella pertussis vaccine is used worldwide, its clinical efficacy has not been documented and its immunomodulatory effect on murine experimental autoimmune myocarditis (EAM) is not known. The aim of this study was to evaluate the effect of B. pertussis vaccine on the development of experimental autoimmune myocarditis in a murine model. Adult female C3H/He mice were immunized with porcine cardiac myosin, and received a subcutaneous injection of pertussis vaccine in the right hind footpad every 2 weeks for 6 weeks after the first immunization. Ten weeks after the first immunization, the mice were challenged by an intraperitoneal injection of myosin and B. pertussis vaccine was applied simultaneously to the immunized group. The mice were sacrificed 30 days after the second immunization for evaluating the clinical and histological evidence of EAM, and flow cytometry and ELISA of cytokine profiles were performed. Myocardial cells were harvested from the immunized and sham-immunized control mice to investigate the effect of pertussis vaccine on the Th1/Th2 cytokine profile in vitro. The B. pertussis vaccine significantly ameliorated the myocarditis, as shown by the following: attenuated disease course, decreased infiltrating cells, and reduced myocardial inflammatory lesions and necrosis. The mice immunized with pertussis vaccine showed a significantly lower expression of Th2 cytokines (IL-4 and IL-5) than that of the sham-immunized mice (p Addressing the challenge of the "second generation" of adolescent substance abuse prevention programs: the training and field testing of a cognitive-behavioral prevention program for social phobia. Two sequential phases were conducted to evaluate the treatment of adolescent social phobia. Phase 1 investigated the

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